Interleukin‐10 Contributes to Macrophage Dysfunction in Acetaminophen‐induced Acute Liver Failure
نویسندگان
چکیده
منابع مشابه
Heparin-like effect contributes to the coagulopathy in patients with acute liver failure undergoing liver transplantation
INTRODUCTION Liver transplantation (LT) in cirrhotics is characterized by severe coagulopathy, associated with a well documented heparin-like effect (HLE) seen by thromboelastography (TEG) after reperfusion. The amount of HLE present in patients with acute liver failure (ALF) and its role in their bleeding tendency before LT has not been investigated. AIM To investigate the presence and exten...
متن کاملOxidative stress contributes to vascular endothelial dysfunction in heart failure.
Congestive heart failure (HF) is characterized by inadequate nitric oxide (NO) production in the vasculature. Because NO is degraded by oxygen radicals, we hypothesized that NO is degraded faster in HF from inadequate peripheral arterial antioxidant reserves. HF was induced in male Sprague-Dawley rats by left coronary artery ligation. Vascular endothelial function was evaluated by measuring the...
متن کاملDownregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury
Ischemia-reperfusion is a common cause for acute kidney injury and can lead to distant organ dysfunction. Glutathione is a major endogenous antioxidant and its depletion directly correlates to ischemia-reperfusion injury. The liver has high capacity for producing glutathione and is a key organ in modulating local and systemic redox balance. In the present study, we investigated the mechanism by...
متن کاملIron contributes to endothelial dysfunction in acute ischemic syndromes.
Acute Ischemic Syndromes To the Editor: Congratulations to Duffy et al1 on their well-written article, “Iron Chelation Improves Endothelial Function in Patients With Coronary Disease.” We completely agree that increased body iron stores may be a risk factor for atherosclerosis and may accelerate endothelial dysfunction in acute ischemic syndromes. Hence, deferoxamine, an iron chelator, should p...
متن کاملCXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction
Chronic liver allograft dysfunction (CLAD) remains the most common cause of patient morbidity and allograft loss in liver transplant patients. However, the pathogenesis of CLAD has not been completely elucidated. By establishing rat CLAD models, in this study, we identified the informative CLAD-associated genes using isobaric tags for relative and absolute quantification (iTRAQ) proteomics anal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.369.9